C-26 | Vascular and Procedural Outcomes of Drug Coated Balloon vs Drug-Eluting Stents in Peripheral Arterial Disease: A Meta-Regression Analysis

There is a paucity of data on the comparison drug-coated balloons (DCB) versus drug-eluting stents (DES) for femoropopliteal lesions. We conducted regression-based meta-analysis to compare DCB DES in peripheral arterial disease (PAD). An online literature search was MEDLINE (EMBASE and PubMed), Cochrane, Web Science using PRISMA strategy from inception till November 2022. Statistical analysis done calculate Odds’ ratios regression rule out effect modifiers including baseline characteristics comorbidities. A total 1139 patients underwent intervention (DCB n=642; n=497). One-year clinical-driven target lesion revascularization (CD-TLR) significantly lower group (OR: 0.67; 95% CI = 0.46 – 0.96; p 0.03). no difference all-cause mortality, primary patency at one year 2 years among DES. Major amputation low (log OR: 0.47; 0.25 0.87; 0.02). Univariate meta-regression results showed modification based demographics, comorbidities, (p > 0.05) all outcomes except post-procedure ABI. In case ABI, hyperlipidemia (- 0.017, p-value 0.034) smoking 0.007, 0.032) weak albeit statistically significant correlation have favorable one-year CD-TLR major rates as compared with PAD. However, both groups had similar two-year CD-TLR, patency, procedural success,